Cancer therapeutic resistance
WebApr 14, 2024 · Sphingosine kinase 1 is a protooncogene associated with therapeutic resistance in breast cancer [164,165] and can be inhibited with the synthetic structural analog of sphingosine, Fingolimod (FTY720) [166,167]. Interestingly, FTY720 inhibits autophagy and triggers apoptosis in trastuzumab-resistant breast cancer cells . WebNational Center for Biotechnology Information
Cancer therapeutic resistance
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WebMar 1, 2024 · Understanding, predicting, and circumventing resistance to targeted cancer therapy is now a major endeavor for translational cancer biologists to undertake. … WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using CRISPR gene scissors, they identified the NAE1 gene as its driver. Inhibiting this resistance mediator by adding the NAE1 inhibitor MLN4924 not only restores the effect of cisplatin, …
Web2 days ago · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using … WebOvercoming intrinsic and acquired resistance of cancer stem/progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic cancers. This review summarizes recent advances in our understanding of the cellular origin and molecular mechanisms at the basis of cancer initiation ...
WebAug 24, 2024 · The ability of a cancer cell to adapt to a new strategy to survive is called "genetic resistance." When researchers developed TKIs for the treatment of cancers such as non-small cell lung ... WebDec 7, 2024 · Introduction. The biggest barrier to cancer therapy is the inevitable emergence of drug resistance. Drug resistance can be divided into two categories according to the behind factors: primary and secondary (Longley and Johnston, 2005).Primary resistance indicates those factors present in the cancer cell or tissue …
WebA new clinical and preclinical study from UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics. Results are published online ahead of print in Cancer Discovery, a journal of the American Association for Cancer …
Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options. Researchers at ... dailymed venetoclaxWebIn the last decades, cancer therapies have substantially improved cancer care and patients’ survival. The introduction of targeted therapies had a major impact on the management of cancer. However, millions of people still die from cancer every year and cancer drug resistance remains the Achilles' heel of cancer chemotherapeutics. biological nitrogen fixation efficiencyWebApr 13, 2024 · Drug resistance is developed when cancer cells become tolerant to treatments such as systemic chemotherapy, targeted therapy, or/and immunotherapy. Resistance to anticancer drugs is a multifactorial phenomenon that occurs through multiple mechanisms. Subpopulations of cancer cells with various genetic composition co … biological nursing for researchWebAug 6, 2024 · At present, the biggest problem facing cancer immunotherapy is to deeply dissect its complex drug resistance mechanisms and adopt effective combination therapy strategies to overcome it. The … biological nitrogen fixation pdfWebTherapeutic resistance is a process which is unpredictable and difficult to model. Therefore, better tools are needed to identify or predict resistance mechanisms. This … biological nitrogen fixation stepsWebAbstract. Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy. In the clinic, therapeutic resistance is largely attributed to tumor heterogeneity. Growing … biological nomenclature was introduced byWebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using … biological nurturing houding