Fgfr2-bicc1

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WebApr 3, 2024 · The presence of FGFR2 fusions or other rearrangements was determined in 104 enrolled patients (96%) with Next Generation Sequencing (NGS) testing. Eighty-eight (81%) patients had in-frame FGFR2 fusions, and BICC1 the most commonly reported fusion partner (n=27, 25%). WebApr 1, 2024 · FGFR2 fusions in iCCA have been associated with a better prognosis [27], [31] and younger age at diagnosis [27], [28] in some studies. They are also mutually exclusive with KRAS and BRAF [20] and ERBB2/BRAF/NRAS alterations [28] in some studies. FGFR2 fusions have been found to be frequently co-altered with mutations in the …

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WebPubMed Central (PMC) WebIn the present work, we present a case of cholangiocarcinoma who had FGFR2-BICC1 rearrangement detected by NGS. A 76-year-old female diagnosed with cholangiocarcinoma underwent four cycles of chemotherapy. The NGS assay showed that the tumor had a FGFR2-BICC1 rearrangement. The patient had a favorable tumor response to sorafenib. select everything of one color in photoshop

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WebIn the present work, we present a case of cholangiocarcinoma who had FGFR2-BICC1 rearrangement detected by NGS. A 76-year-old female diagnosed with … WebJan 22, 2015 · FGFR2–PPHLN1 and the previously reported FGFR2–BICC1 were present in 16% and 38% of iCCA cases, respectively, and were not mutually exclusive. Presence of FGFR2 rearrangements was also... WebApr 2, 2024 · BICC1 is the most common FGFR2 fusion partner in CCA, and the fusion arises as a consequence of a 58-megabase-sized inversion on chromosome 10. We … select exercise on charge 3

Fibroblast growth factor receptor 2 tyrosine kinase fusions

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WebNov 6, 2024 · A 76-year-old female diagnosed with cholangiocarcinoma underwent four cycles of chemotherapy. The NGS assay showed that the tumor had a FGFR2-BICC1 rearrangement. The patient had a favorable tumor response to sorafenib. Herein, we report the first case with cholangiocarcinoma harboring FGFR2-BICC1 who is sensitive to … WebMay 25, 2024 · FGFR3-TACC3 was the most prevalent FGFR rearrangement (29.0%), followed by FGFR2-BICC1 and FGFR2-N/A (both 9.7%). In vitro analysis of the transforming potential and drug sensitivity for select alterations will be reported. select everything rWebApr 12, 2024 · The FGFR2 can be involved in rearrangements with different genes. Although BICC1 is the partner in approximately 30% of FGFR2 fusions detected in iCCA, over 150 partners have been described up to … select express auto chittenango ny

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Fgfr2-bicc1

Clinicogenomic Analysis of FGFR2-Rearranged …

Webtranslation of the FGFR2 gene1 FGFR2b is primarily expressed in epithelial cells1 • Due to its unique extracellular domain, only a specific subset of FGF ligands will bind to the receptor1 2 FGFR2b FGFR2b WebMar 21, 2024 · protein bicaudal C homolog 1, FGFR2-BICC1 fusion kinase protein, bicaudal C homolog 1. GeneRIFs: Gene References Into Functions. miR-101-3p and miR-199b …

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WebDec 3, 2024 · We also observed nine novel FGFR2 SNVs (in addition to others that have been previously reported) in a patient with an FGFR2–BICC1 fusion treated with infigratinib: D651Y, E566G, L551/2F, L551F ... WebNational Center for Biotechnology Information

WebAug 8, 2016 · Cholangiocarcinoma mice model harboring FGFR2-AHCYL1, FGFR2-CCDC6, and FGFR2-BICC1 was sensitive to treatment with FGFR kinase inhibitors BGJ398 and PD173074. [16, 17] TACC3 gene has been identified as an important partner of these FGFR fusions and associated with the pathogenesis of several solid tumors. [18 ... WebFibroblast growth factor receptor 2 ( FGFR2) fusions or rearrangements occur in up to 14% of patients with intrahepatic cholangiocarcinoma. 8-10 Two selective FGFR1–3 inhibitors, pemigatinib and...

WebOct 9, 2013 · The FGFR2-BICC1 fusion gene was detected in one colorectal cancer (0.7%) and one hepatocellular carcinoma (1.0%). These fusion-positive non-ICC cases were also hepatitis virus-positive (Table 1 ). Table 1. Clinical Features of FGFR2 Fusion Positive Cases ICC: Intrahepatic cholangiocarcinoma CRC: colorectal cancer HCC: … WebFeb 13, 2014 · A protein product model is shown only for one of the reciprocal events involving the FGFR2 and BICC1 genes (FGFR2→BICC1, C). The fusion breakpoints of the reciprocal events effect Exons 1 and 2 of the BICC1 gene, which translates to a difference of a predicted phosphoserine site within the Casein kinase II phosphorylation region ( C , …

WebJul 16, 2024 · A biopsy from a lung mass revealed a moderately differentiated adenocarcinoma. Immunohistochemistry (IHC) staining was positive for CK-7 and negative for CK-20, consistent with a lung primary. The programmed death-ligand 1 score was < 1%. The tu-mor harbored an FGFR2-BICC1 fusion in 10.5% of cell-free DNA. The patient …

Web1 day ago · [35], [36] In addition, three different FGFR2 fusion proteins FGFR2/TACC3, FGFR2/MGEA5 and FGFR2/BICC1 that were isolated from intrahepatic cholangiocarcinoma (ICC) samples and the FGFR3 translocation protein in bladder cancer are all reported to be Hsp90 clients. These proteins undergo rapid degradation through ubiquitin conjugation in … select expert in crystal reportsWeb1 day ago · [35], [36] In addition, three different FGFR2 fusion proteins FGFR2/TACC3, FGFR2/MGEA5 and FGFR2/BICC1 that were isolated from intrahepatic … select express dick\u0027s sporting goodsWebJul 28, 2024 · Fifty-six patients (92%) had the exact alteration identified. The most common FGFR genetic alteration seen in our study was the FGFR2-BICC1 fusion (n = 11, 18%). Fifty (82%) patients had an FGFR2 fusion or rearrangement and 11 (18%) patients had other FGFR alterations. select express track orderWebCD51 + CD61 (Integrin alpha V + Integrin beta 3) CD51 / Integrin alpha V. CD52 select external forces of change. quizletWebMay 27, 2024 · The FDA has approved Balversa (erdafitinib) as a treatment for adult patients with locally advanced or metastatic bladder cancer that have FGFR3 or FGFR2 abnormalities and that has progressed during or following … select extensions for sharing with othersWebFeb 2, 2024 · Although the most prevalent FGFR2 partner (BICC1) has a dimerization domain, not all FGFR2 rearrangement partners have known or predicted dimerization domains, suggesting that the pervasiveness of FGFR2 partners may be due to lack of requirement for sequence or functional specificity of partner genes. select extensionpropertyWebUsing these FGFR2 fusion-positive ICC models, we conducted an unbiased high-throughput small molecule screen to prioritize combination strategies with FGFR inhibition, from which HDAC inhibition... select expression in spark