Web5 de out. de 2001 · Direct analysis of HIF-1α revealed that the protein is subject to ubiquitination and proteasomal degradation under nonhypoxic conditions Huang et al. 1998, Kallio et al. 1999, Salceda and Caro 1997, a process that is inhibited under hypoxic conditions (Sutter et al., 2000).O 2-regulated expression of HIF-1α is mediated by a …
Hypoxia-inducible factor 1α protein expression is controlled by …
Web25 de set. de 2024 · Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression and target therapy in cancer. HIF-1α acts differently depending on presence or absence of Oxygen. In an oxygen-immersed environment, HIF-1α … Web基质细胞衍生因子-1(sdf-1)又称趋化因子cxcl12,是小分子的细胞因子,属于趋化因子蛋白家族。它有两种形式,sdf-1α/cxcl12a和sdf-1β/cxcl12b。 phones for hearing aid wearers
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Web12 de mar. de 2024 · Roles of HIF-1α in MIRI. Matsushima et al demonstrated that HIF-1α may protect cardiac fibroblasts from apoptosis and represent a potential therapeutic target for heart remodeling following hypoxic injury.Additionally, a number of studies have confirmed that HIF-1α prevents MIRI and has a cardioprotective effect (22,23).Protective … Web15 de set. de 2024 · Hypoxia‑inducible factor‑1α (HIF‑1α) is essential for regulating the osteogenic differentiation of periodontal ligament cells (PDLCs). The regulatory mechanism of HIF‑1α transcription is still not clear. Recently, two long non‑coding RNAs, HIF1A antisense RNA 1 (HIF1A‑AS1) and HIF1A antisense RNA 2 (HIF1A‑AS2), were found to … Web28 de jul. de 2024 · Overexpression of HIF-1α can lead to increased expression of some genes, facilitating cellular resistance against apoptosis caused by hypoxia or lack of nutrients (Akakura et al., 2001; Yang S. et al., 2024). For example, HIF-1α subunits are involved in regulating the activities of many members of the Bcl-2 family (Fang et al., 2024). phones for hearing aid users